September 27, 1996 saw the beginning of the DHVSU Lubao Campus when the Governing Board of the Don Honorio Ventura State University, then still named the Don Honorio Ventura College of Arts and Trades, approved the opening of a relocation site in Kabuhayan Village, Lubao, Pampanga. After a few years of operation, however, the new campus was closed for an indefinite period due to conflicts concerning the lot on which it stands.
On October 4, 2010, the DHVSU Board of Regents approved the reopening of the Lubao Campus and thus resumed operations. The University entered into a Memorandum of Agreement with the Provincial Government of Pampanga under the leadership of Governor Lilia G. Pineda.
Another agreement between the Municiality of Lubao, represented by Mayor Mylyn P. Cayabyab, and the University ensued on October 30, 2017, legitimately allowing DHVSU to use four parcels of land situated in Sta. Catalina, Lubao, Pampanga. The land was to be used for construction of school buildings for a period of 25 years.
In 2018, through a new memorandum of agreement, the University and the Provincial Government of Pampanga embarked on a joint program to govern the DHVSU Lubao Campus.
The inauguration of the campus was held on May 2, 2018 with House Speaker Gloria M. Arroyo, former Congresswoman of the Second District of Pampanga, as one of the benefactors. Aside from Rep. Arroyo, then-Pampanga Governor Lilia G. Pineda graced the occasion along with officials from the Pampanga Provincial Capitol and Lubao Municipality, as well as the DHVSU Administrative Council.
In June 2019, a revocation of the October 2017 agreement commenced, where the Municipality of Lubao, represented by Mayor Cayabyab as the Donor, officially donated to the University the four parcels of land in Sta. Catalina, Lubao.
